Genetic determinants of Type 1 DM progression Impact of diabetes susceptibility loci on progression from pre-diabetes to diabetes in at-risk individuals of the DPT1 trial
نویسندگان
چکیده
Section on Immunology and Immunogenetics, Joslin Diabetes Center, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02215 Address correspondence to: Diane Mathis and Christophe Benoist Section on Immunology and Immunogenetics Joslin Diabetes Center One Joslin Place, Boston, MA 02214 email: [email protected] Received 11 December 2007 and accepted 5 June 2008. Additional information for this article can be found in an online appendix at http://diabetes.diabetesjournals.org
منابع مشابه
Impact of Diabetes Susceptibility Loci on Progression From Pre-Diabetes to Diabetes in At-Risk Individuals of the Diabetes Prevention Trial–Type 1 (DPT-1)
OBJECTIVE The unfolding of type 1 diabetes involves a number of steps: defective immunological tolerance, priming of anti-islet autoimmunity, and destruction of insulin-producing beta-cells. A number of genetic loci contribute to susceptibility to type 1 diabetes, but it is unclear which stages of the disease are influenced by the different loci. Here, we analyzed the frequency of type 1 diabet...
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